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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4⁺, CD8^{+OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activationHowever, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limitedIn the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robustTaken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast}

Keywords： BGB-A445 OX40 agonistic antibody OX40L noncompetitive

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: The cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.The maximum increase of about 40% was observed.These results indicated that IL-10 can effectively prevent the formation of foam cells induced by ox-LDLThis study demonstrates that ox-LDL can cause foam cell formation from macrophages .IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.

Keywords： inflammatory presence interleukin-10 dose-dependent ox-LDL

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The Potential Role of Powdery Mildew-Resistance Gene Pm40 in Chinese Wheat-Breeding Programs in Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4, Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract: Pm40 was identified and mapped on the wheat chromosome arm 7BS from several wheat lines developedPm40 offers a broad spectrum of resistance to Bgt, which suggests that it is likelyLines with Pm40 and promising agronomical traits have been released by several wheat-breedingTherefore, we believe that Pm40 will play a role in powdery mildew-resistance wheat breedingIn addition, both Pm21 and Pm40 were derived from alien species, suggesting that the

Keywords： Wheat Powdery mildew Pm21 Pm40 Alien species Native resistance

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Coming Back from a Trip on High-Speed Trains in the 2040s

Ignacio Barron

Engineering 2016, Volume 2, Issue 3, Pages 292-293 doi: 10.1016/J.ENG.2016.03.020

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Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine” [Engineering 5 (2019) 40 Corrigendum

Yan-Meng Lu, Jiao-Jiao Xie, Cong-Gao Peng, Bao-Hong Wang, Kai-Cen Wang, Lan-Juan Li

Engineering 2019, Volume 5, Issue 4, Pages 811-812 doi: 10.1016/j.eng.2019.05.004

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Forty Years of the Faster-than-Light Research—Review and Prospects

Huang Zhixun

Strategic Study of CAE 2004, Volume 6, Issue 10, Pages 6-23

Abstract:

Work on faster-than-light (superluminal) research has been going on in USA, Europe and PRC since the early work of O. M. Bilanuik and E. C. Sudarshan in 1962 and that of a good working with G. Feinberg at Columbia University in 1967.

According to the original article of A. Einstein in 1905, velocities greater than that of light have no possibility of existence. However, an interesting phenomenon related to the Einstein's article in 1907 have been found, in which the possibility of sending signals in superluminal communication was not completely negated. In this paper, the author tries to bring about split-up to the different subjects of velocity's study，and then, suggests the definition of General Information Velocity (GIV) to make better discussion of those velocity concepts. After rethinking superluminal research in 1962—2003，the author obtains the conclusion that the “faster than the speed of light in vacuum” is a realizable scientific statement.

Keywords： relalivity quantum mechanics superluminal (faster-than-light) tachyons negative velocity information velocity